root of Panax ginseng C.A.meyer are one of the most important
oriental crude drugs used for a psychiatric, neurologic and diabetes
mellitus treatment. Researchers from japan isolated sixteen acetylenic
compounds from the roots of this plant and tested them for their
cytotoxic activites on murine and human malignant cells in vitro.
Some of the acetylenes showed more potent cytotoxicity than 5-fluoroursil
(5-FU) and cisplatin (CDDP). Of the active compounds, panaxydol
showed the most potenet cytotoxic activity.
acetylenic compound were tested for their cytotoxicity using murine
and human malignant cell lines, Kirsten murine sarcoma virus-transformed
NIH/3T3 (DT cells), mouse fibroblast NIH/3T3 cells, murine lymphoma
L1210 cells and human mammary carcinoma MCF7 cells in vitro. The
results showed that the acetylenic compounds isolated from the
root possesses cytotoxic effects on several cancer cells and could
be lead compound for usefulchemotherapeutic agents (Hirakuraetal,NaturalMed,2000,54,342).